Memory and the NMDA Receptors
نویسندگان
چکیده
منابع مشابه
NMDA receptors and memory encoding.
It is humbling to think that 30 years have passed since the paper by Collingridge, Kehl and McLennan showing that one of Jeff Watkins most interesting compounds, R-2-amino-5-phosphonopentanoate (d-AP5), blocked the induction of long-term potentiation in vitro at synapses from area CA3 of the hippocampus to CA1 without apparent effect on baseline synaptic transmission (Collingridge et al., 1983)...
متن کاملNMDA Receptors Mediate Olfactory Learning and Memory in Drosophila
BACKGROUND Molecular and electrophysiological properties of NMDARs suggest that they may be the Hebbian "coincidence detectors" hypothesized to underlie associative learning. Because of the nonspecificity of drugs that modulate NMDAR function or the relatively chronic genetic manipulations of various NMDAR subunits from mammalian studies, conclusive evidence for such an acute role for NMDARs in...
متن کاملAssessment of the role of NMDA receptors located in hippocampal CA1 area on the effects of oral morphine dependency on spatial learning and memory in rat
Introduction: It has been reported that oral morphine dependency facilitated formation of spatial learning and memory. In the present study the role of NMDA receptors located in hippocampal CA1 area of morphine dependent rats was studied. Methods: Male rats were divided into 4 groups. Two cannulae were stereotaxically implanted bilaterally into the hippocampal CA1 area. After 5 days recover...
متن کاملRequirement for hippocampal CA3 NMDA receptors in associative memory recall.
Pattern completion, the ability to retrieve complete memories on the basis of incomplete sets of cues, is a crucial function of biological memory systems. The extensive recurrent connectivity of the CA3 area of hippocampus has led to suggestions that it might provide this function. We have tested this hypothesis by generating and analyzing a genetically engineered mouse strain in which the N-me...
متن کاملThe Ins and Outs of NMDA Receptors
Although the trafficking of AMPA receptors has received much recent fanfare as a mechanism for synaptic plasticity, NMDA receptors have received less attention in this regard. However, Scott et al. now show that independent regions within the cytoplasmic domains of NMDA receptor type 1 (NR1) and NMDA receptor type 2 (NR2) subunits target NMDA receptors for internalization. Interestingly, the re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2009
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmcibr0902052